Indigenous Peoples have used plants, trees, and other natural materials they call sacred medicines to promote healthy living and cure illness, and during ceremonies. The most common sacred medicines used for ceremonies are tobacco, cedar, sage, and sweetgrass.

It is important to follow a traditional protocol that pays respect to Mother Earth when harvesting sacred plants; therefore, indiscriminate picking of these plants is disrespectful. Teachings about traditional plants and uses, including traditional protocol, should be guided by local Elders, Knowledge Keepers, or Cultural Advisors.